Xuan Zhao,Michael D. Bentley,Zhongxu Ren,Tacey X. Viegas
申请号：
US12728072
公开号：
US08318145B2
申请日:
2010.03.19
申请国别(地区):
US
年份:
2012
代理人:
摘要：
Provided herein are water-soluble prodrugs. The prodrugs of the invention comprise a water-soluble polymer having three or more arms, at least three of which are covalently attached to an active agent, e.g., a small molecule. The conjugates of the invention provide an optimal balance of polymer size and structure for achieving improved drug loading, since the conjugates of the invention possess three or more active agents releasably attached to a multi-armed water soluble polymer. The prodrugs of the invention are therapeutically effective, and exhibit improved properties in-vivo when compared to unmodified parent drug.
