Combinations comprising 6-benzylphenyl-2-sulfurterahydropyran-3,4,5-triol derivatives as sodium-glucose 1 and 2 cotransporter inhibitors for use in diabetic patients
BROWN, Philip Manton,FREIMAN, Joel Philip,POWELL, David Reed
申请号：
ES11707324
公开号：
ES2609104T3
申请日:
2011.03.01
申请国别(地区):
ES
年份:
2017
代理人:
摘要：
Dose of 300 mg / day or less (eg, 250, 200, 150, 100 or 50 mg / day or less) of a dual SGLT1 / 2 inhibitor of the formula: ** Formula ** or a pharmaceutically acceptable salt of same, for use in improving the cardiovascular or metabolic health of a diabetic or prediabetic patient currently taking a DPP-4 inhibitor, wherein: each R1A is independently hydrogen, alkyl, aryl, or heterocycle； each R6 is independently hydrogen, hydroxyl, amino, alkyl, aryl, cyano, halogen, heteroalkyl, heterocycle, nitro, C≡CR6A, OR6A, SR6A, SOR6A, SO2R6A, C (O) R6A, CO2R6A, CO2H, CON (R6A) (R6A), CONH (R6A), CONH2, NHC (O) R6A or NHSO2R6A； each R6A is independently alkyl, aryl, or heterocycle； each R7 is independently hydrogen, hydroxyl, amino, alkyl, aryl, cyano, halogen, heteroalkyl, heterocycle, nitro, C≡CR7A, OR7A, SR7A, SOR7A, SO2R7A, C (O) R7A, CO2R7A, CO2H, CON (R7A) (R7A), CONH (R7A), CONH2, NHC (O) R7A, or NHSO2R7A； each R7A is independently alkyl, aryl, or heterocycle； m is 1-4； n is 1-3； p is 0-2； and wherein each alkyl, aryl, heteroalkyl, or heterocycle is optionally substituted by one or more of alkoxy, amino, cyano, halo, hydroxyl, or nitro, and wherein the DPP-4 inhibitor is sitagliptin.Dosis de 300 mg/día o menos (por ejemplo, 250, 200, 150, 100 o 50 mg/día o menos) de un inhibidor de SGLT1/2 dual de la fórmula:**Fórmula** o una sal farmacéuticamente aceptable del mismo, para su uso en la mejora de la salud cardiovascular o metabólica de un paciente diabético o prediabético que toma actualmente un inhibidor de DPP-4, en la que: cada R1A es independientemente hidrógeno, alquilo, arilo o heterociclo； cada R6 es independientemente hidrógeno, hidroxilo, amino, alquilo, arilo, ciano, halógeno, heteroalquilo, heterociclo, nitro, C≡CR6A, OR6A, SR6A, SOR6A, SO2R6A, C(O)R6A, CO2R6A, CO2H, CON(R6A)(R6A), CONH(R6A), CONH2, NHC(O)R6A o NHSO2R6A； cada R6A es independientemente alquilo, arilo o heterociclo； cada R7 es independientemente hidrógeno, hidroxilo, amino, alquilo, arilo, cian
