Disclosed herein is a pyrazolotriazolopyrimidine derivative or a stereoisomer thereof, or a pharmaceutically acceptable salt thereof useful as an A2A receptor antagonist, and a pharmaceutical composition comprising the same. Also disclosed herein is a method of treating cancer using the pyrazolotriazolopyrimidine derivative or a stereoisomer thereof, or a pharmaceutically acceptable salt thereof as an A2A receptor antagonist.本文公開了一種用作A2A受體拮抗劑的吡唑並三唑並嘧啶衍生物或其立體異構物或其醫藥上可接受的鹽，以及一種包含吡唑並三唑並嘧啶衍生物或其立體異構物或其醫藥上可接受的鹽的醫藥組合物。本文還公開了一種使用該吡唑並三唑並嘧啶衍生物或其立體異構物或其醫藥上可接受的鹽作為A2A受體拮抗劑治療癌症的方法。
