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2 Molecules from polymerization to antgeno include a triangular relationship that binds to the FNT family and a part that binds to Turner
专利权人:
F. HOFFMANN-LA ROCHE AG
发明人:
申请号:
ARP170101252
公开号:
AR108452A1
申请日:
2017.05.11
申请国别(地区):
AR
年份:
2018
代理人:
摘要:
2. The application relates to an antigen binding molecule containing a triplet of the FNT family, including: (a) at least a part of the antigen binding molecule that can specifically bind to Turner C (TNC), and (b) the first and second polypeptide compounds connected together by a disulfide link, In this case, the antigen binding molecule is characterized by that the first polypeptide consists of two shells of a phenyl junction or two parts connected by a phenyl junction, while the second polypeptide consists of only one phenyl junction.A member or part of the FNT alliance. The request also relates to methods of producing and using these molecules. 11. Claim 11: any one to ten claims contain antigen binding molecules with triple bond of national front familyThe parts that can be specifically linked to TNC include VH field, including: (1) cdr-h1, including SEQ amino acid sequence No. 67, (2) cdr-h2, including SEQ amino acid sequence No. 68, e (3) CDR-H3, including SEQ amino acid sequence No. 69, and (4) VL field in which cdr-l1 is included. Including the amino acid sequence of SEQ No. 55 (II) cdr-l2, including the amino acid sequence of SEQ No. 56,Y (VI) cdr-l3 includes amino acid sequence SEQ ID No.57. Claim 12: the antigen binding molecule, which contains any triplet that connects the National Front family according to any one of claims 1 to 10, and the part that can be specifically linked to TNC includes VH field, including: (I) cdr-h1, including the amino acid sequence of SEQ ID No.70, (II) cdr-h2, including the amino acid sequence of SEQ ID No.71, e (III) CDR-H3, including the amino acid sequence of SEQ ID No.72, and VL domain including (IV) cdr-l1, including the amino acid sequence of SEQ ID No.58,(II) cdr-l2, including the amino acid sequence of SEQ No. 59 and (VI) cdr-l3, including the amino acid sequence of SEQ No. 60.La solicitud se refiere a moléculas de unión a antígeno que contienen trímero ligando de la familia de FNT, que comprenden: (a) por lo menos
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