YURKOVETSKIY, ALEKSANDR,YIN, MAO,LOWINGER, TIMOTHY B.,THOMAS, JOSHUA D.,HAMMOND, CHARLES E.,STEVENSON, CHERI A.,BODYAK, NATALYA D.,CONLON, PATRICK R.,GUMEROV, DMITRY R.
申请号：
CA2837840
公开号：
CA2837840A1
申请日:
2012.06.11
申请国别(地区):
CA
年份:
2012
代理人:
摘要：
A drug conjugate is provided herein. The conjugate comprises a protein based recognition-molecule (PBRM) and a polymeric carrier substituted with one or more -LD-D, the protein based recognition-molecule being connected to the polymeric carrier by Lp. Each occurrence of D is independently a therapeutic agent having a molecular weight = 5 kDa. LD and Lp are linkers connecting the therapeutic agent and PBRM to the polymeric carrier respectively. Also disclosed are polymeric scaffolds useful for conjugating with a PBRM to form a polymer-drug-PBRM conjugate described herein, compositions comprising the conjugates, methods of their preparation, and methods of treating various disorders with the conjugates or their compositions.
