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METHODS AND COMPOSITIONS RELATING TO PROTEASOME INHIBITOR RESISTANCE
专利权人:
发明人:
Peter Tsvetkov,Sandro Santagata,Susan Lindquist
申请号:
US15870747
公开号:
US20180353445A1
申请日:
2018.01.12
申请国别(地区):
US
年份:
2018
代理人:
摘要:
In some aspects, the disclosure provides methods of modulating the level of proteasome inhibitor resistance of a cell, the methods comprising manipulating the level of expression or activity of a subunit of the 19S proteasome in the cell. In some aspects, cells in which the level of a 19S subunit is modulated, e.g., reduced, are provided. In some aspects, methods of identifying agents that reduce proteasome inhibitor resistance are provided. In some aspects, methods of classifying cancers according to predicted proteasome inhibitor resistance are provided. In some aspects, methods of killing or inhibiting proliferation of cancer cells, e.g., proteasome inhibitor resistant cancer cells, are provided. In some aspects, methods of treating cancer, e.g., proteasome inhibitor resistant cancer, are provided.
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