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Acylthiourea compound or salt thereof, and use thereof
专利权人:
Yoshimitsu Suda;Hidenori Fujita;Kosuke Egami
发明人:
Yoshimitsu Suda,Kosuke Egami,Hidenori Fujita
申请号:
US12937312
公开号:
US08304427B2
申请日:
2009.04.09
申请国别(地区):
US
年份:
2012
代理人:
摘要:
Provided is a c-Met inhibitory antitumor agent which mitigates side effects by selectively affecting tumor cells in which c-Met is specifically expressed, having a formula (I) or its salt:wherein each of R1 and R2 are independently a hydrogen atom, an optionally substituted C1-6 alkyl, C3-10 cycloalkyl, C6-14 aromatic hydrocarbon, or saturated or unsaturated heterocyclic group, or R1 and R2 may form, together with the nitrogen atom to which they are attached, an optionally substituted nitrogen-containing heterocyclic ring; R3 is a C1-6 alkyl group; and R4, R5, and R6, are independently a hydrogen atom, a halogen atom, an optionally substituted C1-6 alkyl group, a C1-6 alkoxy group, a C1-6 alkylamino group, an optionally substituted aromatic hydrocarbon group, or an optionally substituted saturated or unsaturated heterocyclic group, or R5 and R6 may form a ring together with the phenyl ring to which they are attached.
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