УЭЙЧЕРТ Джейми П. (US),ПИНЧУК Анатолий (US),КАНДЕЛА Травати (US),ЛОНДЖИНО Марк (US),КЛАРК Уилльям Р. (US)
申请号：
RU2012100765/15
公开号：
RU2012100765A
申请日:
2010.06.11
申请国别(地区):
RU
年份:
2013
代理人:
摘要：
1. A method of treating cancer, comprising administering to a patient in need thereof a therapeutically effective amount of a radioactively labeled ether or alkyl phospholipid derivative of Formula I Formula I where X is an iodine isotope； n is an integer from 12 to 30； and Y is selected from the group consisting of NH, HN (R), NHR and N (R), in which R represents an alkyl or arylalkyl substituent, or Formula II Formula II wherein X is an iodine isotope； n is an integer from 12 to 30； Y is selected from the group consisting of H, OH, COOH, COOR and OR, and Z is selected from the group consisting of NH, HN (R), NHR and N (R), in which R is an alkyl or arylalkyl substituent in which said therapeutically effective amount of said radiolabeled ethereal or alkyl phospholipid compound is sufficient to penetrate said cancer stem cells, and in which the population of said cancer stem cells is reduced. The method of claim 1, wherein said cancer stem cell population comprises the following types of cancer stem cells: glioma, lung cancer, squamous cell carcinoma, kidney cancer, melanoma, colorectal cancer, ovarian cancer, prostate cancer, breast cancer, and pancreatic cancer. 3. The method according to claim 1, wherein said iodine isotope is I. 4. The method of claim 1, wherein said radiolabeled ether or alkyl phospholipid derivative is 18- (p-iodophenyl) octadecylphosphocholine and X is I. 5. The method of claim 1, wherein X is two or three isotopes of iodine. The method according to claim 1, wherein said method further comprises another type of cancer therapy selected from the group consisting of1. Способ лечения рака, включающий введение пациенту, нуждающемуся в этом, терапевтически эффективного количества радиоактивномеченного эфирного или алкильного фосфолипидного производного Формулы IФормула Iгде X представляет собой изотоп йода； n является целым числом от 12 до 30； и Y выбран из группы, содержащей NH, HN(R), NHR и N(R), в которой R представляет собой алкильный или арила
