Andrei W. Konradi,Robert A. Galemmo, JR.,Stephen S. Dominy,Casey C. Lynch,Leslie J. Holsinger
申请号：
US16353786
公开号：
US20190210960A1
申请日:
2019.03.14
申请国别(地区):
US
年份:
2019
代理人:
摘要：
The present invention provides compounds according to Formula I as described herein, and their use for inhibiting the lysine gingipain protease (Kgp) from the bacterium Porphyromonas gingivalis. Also described are gingipain activity probe compounds and methods for assaying gingipain activity are also described, as well as methods for the treatment of disorders associated with P. gingivalis infection, including brain disorders such as Alzheimer's disease.
