A hyaluronic acid synthesis promoter or HAS2 mRNA expression promoter containing, as an active ingredient, at least a first fraction containing chrysin that is a fraction extracted from seeds of Oroxylum indicum by an aqueous organic solvent, another fraction obtained by purifying the first fraction, or chrysin. Also, a pharmaceutical, food, or cosmetic containing this hyaluronic acid synthesis promoter or HAS2 mRNA expression promoter. This hyaluronic acid synthesis promoter, HAS2 mRNA expression promoter, pharmaceutical, food, or cosmetic serves as a useful item using a fraction or component obtained from highly safe Oroxylum indicum.本發明的課題為提供[使用由安全性高的千張紙得到的分劃物或成分之玻尿酸合成促進劑]、[使用由安全性高的千張紙得到的分劃物或成分之HAS2mRNA表現促進劑]、[含有本發明的玻尿酸合成促進劑,具有玻尿酸合成促進作用的醫藥品、食品或化妝料]及[含有本發明的HAS2mRNA表現促進劑,具有HAS2mRNA表現促進作用的醫藥品、食品或化妝料]。本發明的解決手段為一種玻尿酸合成促進劑或HAS2mRNA表現促進劑,含有以由千張紙的種子藉由水性有機溶劑萃取的分劃物,且至少包含金黃酮之第一分劃物,將第一分劃物精製而得的其他的分劃物或金黃酮為有效成分。而且,一種醫藥品、食品或化妝料含有本發明的玻尿酸合成促進劑或HAS2mRNA表現促進劑。
