Qi-Jing Li;Chang-Zheng Chen;Jacqueline Chau;Mark M. Davis
发明人:
Qi-Jing Li,Chang-Zheng Chen,Mark M. Davis,Jacqueline Chau
申请号：
US12792585
公开号：
US08741860B2
申请日:
2010.06.02
申请国别(地区):
US
年份:
2014
代理人:
摘要：
MicroRNAs (miRNAs) are a diverse and abundant class of ˜22-nucleotide (nt) endogenous regulatory RNAs that play a variety of roles in animal cells by controlling gene expression at the posttranscriptional level. Increased miR-181a expression in mature T cells is shown to cause a marked increase in T cell activation and augments T cell sensitivity to peptide antigens. Moreover, T cell blasts with higher miR-181a expression become reactive to antagonists. The effects of miR-181a on antigen discrimination are in part achieved by dampening the expression of multiple negative regulators in the T cell receptor (TCR) signaling pathway, including PTPN22 and the dual specificity phosphatases DUSP5 and DUSP6. This results in a reduction in the TCR signaling threshold, thus quantitatively and qualitatively enhancing T cell sensitivity to antigens.
