Compounds derived from imidazo [1,2-a] pyridine as inhibitors of kinases and / or c-kit and PDGFR； Pharmaceutical composition that comprises； and their use in treating a disease associated with mast cells, a Respiratory disease, a Metabolic Disease, an autoimmune Disorder, a condition Dermatology, among others.
MOLTENI, VALENTINA,YEH, VINCE,LI, XIAOLIN,LIU, XIAODONG,LOREN, JON,NABAKKA, JULIET,NGUYEN, BAO,PETRASSI, HANK MICHAEL JAMES
申请号：
CL2014000494
公开号：
CL2014000494A1
申请日:
2014.02.27
申请国别(地区):
CL
年份:
2014
代理人:
摘要：
The invention provides compounds and pharmaceutical compositions thereof, which are useful as protein kinase inhibitors, as well as methods for using such compounds to treat, ameliorate or prevent a condition associated with abnormal or deregulated kinase activity. In some embodiments, the invention provides methods for using such compounds to treat, ameliorate or prevent diseases or disorders that involve abnormal activation of c-kit or c-kit and PDGFR (PDGFR&alpha；, PDGFR&bgr；) kinases.COMPUESTOS DERIVADOS DE IMIDAZO[1,2-A]PIRIDINA, INHIBIDORES DE QUINASA PDGFR Y/O C-KIT； COMPOSICION FARMACEUTICA QUE LOS COMPRENDE； Y SU USO EN EL TRATAMIENTO DE ENFERMEDADES ASOCIADAS CON MASTOCITOS, RESPIRATORIA, METABOLICA, DERMATOLOGICA, ENTRE OTRAS.
