To treat diseases accompanied by degenerative intervertebral discs, in particular, disk herniation, lumbar pain, discopathy and osteoarthritits of the spine, it is intended to provide a drug for administering a human-origin protease directly to an affected part of such a disease accompanied by degenerative intervertebral discs. As the human-origin protease, use can be made of MMP-3, MMP-7, etc.