TRIAZINE COMPOUNDS AS PI3 KINASE AND MTOR INHIBITORS Compounds of formula I wherein: R 1 is and R 2 , R 4 , and R 6-9 are defined herein, and pharmaceutically acceptable salts and esters thereof. These compounds inhibit PI3 kinase and mTOR, and may be used to treat diseases mediated by PI3 kinase and mTOR, such as a variety of cancers. Methods for making and using the compounds of this invention are disclosed. Various compositions containing the compounds of this invention are also disclosed.Jedinjenja formule, (I) gde: R 1 predstavlja (II) ili (III)； a R 2 , R 4 i R 6-9 su ovde definisani, i njihove farmaceutski prihvatljive soli i estri. Ova jedinjenja inhibiraju PB kinazu i mTOR, i mogu se koristiti za tretiranje bolesti posredovanih sa PB kinazom i mTOR, kao što su razni kanceri. Opisani su postupci za pravljenje i upotrebu jedinjenja iz ovog pronalaska. Opisane su takođe razne kompozicije koje sadrže jedinjenja iz ovog pronalaska.
