The present invention discloses an extract of Antrodia cinnamomea and pharmaceutical application thereof. As confirmed by the researches of the present invention, said extract of Antrodia cinnamomea is able to decrease the activities of hepatic stellate cell and therefore obtain the efficacy of liver fibrosis prevention and/or treatment. Accordingly, the present invention dislcoses a novel pharmaceutical application of Antrodia cinnamomea and provides an alternative prevention and/or treatment regime of liver fibrosis for the field.本發明提供了一種預防及/或治療肝纖維化的醫藥組合物及其用途,具體揭露一種牛樟芝萃取物及其醫藥應用,所述牛樟芝萃取物為5-甲基-苯并[1,3]二氧-4,7-二醇(5-methyl-bcnzol[1,3]dioxolc-4,7-diol,MBDD)。經實驗證實,本發明牛樟芝萃取物可抑制星狀細胞的活性,從而達到預防及/或治療肝纖維化的效果。據此,本發明揭露牛樟芝萃取物的新穎醫藥應用,更提供領域中預防及/或治療肝纖維化的替代選擇。
