Method and apparatus for a pre-term infant mattress having a plurality of upstanding air chambers connected together pneumatically which air chambers generally surround the infant except for an open area above the head of the infant. Taller outer air chambers constrain the infant laterally wherein shorter inner air chambers provide a womb-like area on the sides of the infant. The air chambers are disposed on a pad having an inner central area with no air chamber to accommodate x-rays of the infant. An air tube is provided for supplying air to the individual air chambers having an air valve for adjusting the air pressure within the air mattress.