FC REGION VARIANT

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专利权人:

发明人:

MIMOTO FUTA,KATADA HITOSHI,IGAWA TOMOYUKI

申请号：

IN9917/DELNP/2015

公开号：

IN2015DN09917A

申请日:

2015.10.23

申请国别(地区):

IN

年份:

2016

代理人:

摘要：

It is iound that a polypeptide, which contains an antibody F c region variant that comprises an amino acid sequence composed of a combination of an alteration of an amino acid residue located at position-238 as numbered in accordance with the E U index and an alteration of another specific amino acid residue, has a reduced binding activity to all of active FcyRs, especially to FcyRIIa (type R), compared with polypeptides each containing a naturally occurring IgG F c region, while maintaining the binding activity thereof to FcyRIIb.

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