Ligation of stapled polypeptides

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专利权人:

发明人:

Gregory L. Verdine,Eileen Jeanne Kennedy

申请号：

US14748287

公开号：

US09458189B2

申请日:

2015.06.24

申请国别(地区):

US

年份:

2016

代理人:

摘要：

The present invention provides technology for making large (e.g., greater than 50 amino acids), semi-synthetic, stapled or stitched proteins. The method essentially involves ligating a synthetically produced stapled or stitched peptide to a larger protein. Modified version of IL-13 and MYC are provided as illustrative examples.

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