The present invention provides methods and kits for treating hyperparathyroidism,bone disease and/or hypercalcemic disorders. In particular, methods for loweringserum PTH and serum calcium using polycationic calcium modulator peptides areprovided. The calcium modulator peptides can be used to treat subjects having,for example: primary, secondary or tertiary hyperparathyroidism; hypercalcemiaof malignancy; metastatic bone disease; or osteoporosis.