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NOVEL NEUROKININ 1 RECEPTOR ANTAGONIST COMPOUNDS II
专利权人:
发明人:
申请号:
EP14806546.9
公开号:
EP3036236A1
申请日:
2014.08.15
申请国别(地区):
EP
年份:
2016
代理人:
摘要:
The invention relates novel NK1 receptor antagonists represented in formula A, wherein R1 and R2 independently are selected from the group consisting of (C1-4)alkyl, (C1-4)haloalkyl, (C1-4)alkoxy, CD3 or halogen R3 is selected from the group consisting of hydrogen, (C1-4)alkyl, (C1-4)haloalkyl and (C1-4)hydroxyalkyl R4 is selected from the group consisting of phenyl, 5-membered heteroaryl and 6-membered heteroaryl R5 and R6 are independently selected from the group consisting of hydrogen, (C1-4)alkyl, (C1-4) hydroxyalkyl and (C1-4)haloalkyl and X and Y are independently selected from the group consisting of CH and N. The invention furthermore relates to intermediates for the preparation of said compounds, to their use in therapy, and to pharmaceutical compositions comprising said compounds.
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