Francesca Ferrera;Antonio La Cava;Gilberto Filaci;Bevra H. Hahn;Marta Rizzi;Francesco Indiveri
发明人:
Antonio La Cava,Bevra H. Hahn,Gilberto Filaci,Francesca Ferrera,Marta Rizzi,Francesco Indiveri
申请号：
US12595676
公开号：
US20120141515A1
申请日:
2008.04.11
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The disclosure provides methods and compositions useful for treating autoimmune diseases and disorders. For example, the disclosure demonstrates that hypergammaglobulinemia and subsequent accelerated kidney disease can be suppressed by Ig minigene-induced CD8+ T cells that make CD4+ T cells hyporesponsive to antigenic stimulation, thus causing inhibition of renal disease and subsequent increased survival.
