A compound of structure 1 ** Formula ** in which X is selected from O, S, CH2, and NH； Y is selected from H, OH, NHCHO, OCOCH3, OCH3, OC2H5, CH3SO3, NO2, CN, CF3, OCF3, F, Br, I, and Cl； ** Formula ** in which Z is S； -X1 is selected from -H, -OH, -OCH3, -OC2H5, OC3H7, -CONH2, -CH2OCONH2, -CH2OCOCH3, -OCOCH3, - CH2OCOCH3, -CH2OCH3, -CH3, -C2H5, -C3H7, -C4H9, C5H11 , C6H13, -Cl, -F, -Br, -I, -HC>； = CHCH3, -HC>； = CH2, -CH2OCH3, ** Formula ** in which R5 is selected from H, CONH2, CH2CH2N (CH3) 2, CH2CH2N (CH2CH3) 2, Cl, F, Br, I, alkyl residues having 1 to 12 carbon atoms, alkyloxy residues having 1 to 12 carbon atoms, alkenyl residues having up to 12 carbon atoms, and alkynyl residues having up to 12 carbon atoms； Rs- is selected from: ** Formula ** R61OOCCH (NHR71) (CH2) nCONH-, R61OOCCH (NHR7) (CH2) nSCONH-, CF3SCH2CONH-, CF3CH2CONH-, CHF2SCH2CONH-, CH2FSCH2CONCH-, NH2COCH-, NH2COCH-2, NH2COCH-, NH2COCH-2, NH2COCH-, NH2COCH-, NH2COCH-, NH2COCH-, NH2CHCH-2, CH2COCH-, NH2CHCH-2, CH2COCH-, NH2CHCH-2, CH2COCH-, NH2CHCH-2, CH2COCH-, NH2COCH-, NH2COCH-, NH2COCH-, NH2CHCH-2, CH2COCH-, NH2CHCH-2, CH2COCH- (NH2COCH-) , CH2SCH2CONH-, CNCH2SCH2CONH-, CH3 (CH2) nCONH-, R71N>； = C (NR71) CH2CH2S-, R71N>； = C (NHR71) NHCO-, CH3C (Cl)>； = CHCH2SCH2CONH-, (CH3) 2C (OR61) -, CNCH2CONH-, CNCH2CH2S-, R71N>； = C (NR71) CH2CH2S-, CH2>； = CHCH2SCH2CONH-, CH3CH (OH) -, CH3CH (OR81) -, CH3CH (Y11) -, (CH3) 2CH-, CH3CH2- , and CH3 (CH2) nCH>； = CH (CH2) mCONH-, or Rs and Y taken together are R61OCH2C (R51)>； =, in which n and m each independently are selected from 0, 1, 2, 3, 4, 5, and 6； X31 is selected from H, N3, SO3W, F, Cl, Br, I, OH, OCH3, OC2H5, CH3, and C2H5； X41 is N or CH； X51 is selected from CH2, S, O, and NH； R51 is selected from H, -CONH2, CH2CH2N (CH3) 2, CH2CH2N (CH2CH3) 2, CH2CH2OR61, Cl, F, Br, I, alkyl residues having 1 to 12 carbon atoms, alkyloxy residues having 1 to 12 carbon atoms, alkenyl residues having up to 12 carbon atoms, alkynyl residues ha
