БРОМЭДЖ Роберт Джозеф Дж. (US),ФЭН Сяо (US),ХОНГ Сёкджу (US),ЛЭНДС Грегори (US),ЛЬЮ Джефф (US),ПОТТЕР Дэвид Джордж (US),ПАУВЕЛЛ Дэвид Рид (US)
申请号：
RU2013123793/10
公开号：
RU2013123793A
申请日:
2011.11.22
申请国别(地区):
RU
年份:
2014
代理人:
摘要：
1. A monoclonal antibody that binds to NOTUM human pectinacetyl esterase (NOTUM) and neutralizes at least one action of NOTUM. 2. The antibody according to claim 1, characterized in that the antibody binds to NOTUM selected from NOTUM mouse, NOTUM guinea pig, NOTUM cynomolgus monkey and NOTUM rhesus monkey. The antibody according to claim 1, characterized in that the antibody reduces the activity of NOTUM during the analysis of trisodium 8-octanoyloxypyrene-1,3,6-trisulfonate (OPTS) in vitro, and / or reduces the activity of NOTUM during analysis of Wnt signal transmission in vitro .four. The antibody according to claim 1, characterized in that, when administered to a subject, such an antibody increases serum PINP levels in vivo, increases the mineral density of the bone in vivo, increases the cortical density of the middle part of the femur in vivo, increases the surface area of the middle part of the femur in vivo, increases cortical density of the middle part of the humerus in vivo, increases endocortical bone formation in vivo, increases the ratio of the cortical bone volume in the vertebral body LV5 in vivo, and / or increases the ratio of the volume of bone tissue of the neck of troubles ennoy bone to the total volume of the femoral neck in vivo.5. The antibody according to claim 1, characterized in that such an antibody binds to a polypeptide with the amino acid sequence of SEQ ID NO: 1 with a value of K less than 50 nM. The antibody according to claim 5, characterized in that the value of K is less than 20 nm. The antibody according to claim 6, characterized in that the K value is less than 10 nM. An antibody according to any one of claims 1 to 5, characterized in that such an antibody has at least one binding characteristic selected from the following: a. binds to a polypeptide with the amino acid sequence of SEQ ID NO: 83 with binding affinity,1. Моноклональное антитело, связывающееся с NOTUM пектинацетилэстеразой человека (NOTUM) и нейтрализующее, по мень
