Cytotoxic protein comprising a cell targeting binding domain for selective killing of specific cell types and a Shiga toxin A subunit domain

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专利权人:

テンプレーツ，インク．;モレキュラー

发明人:

ポーマ エリック,ウィラート エリン,キム ジェイソン,ヒギンス ジャック

申请号：

JP2016501176

公开号：

JP6548630B2

申请日:

2014.03.11

申请国别(地区):

JP

年份:

2019

代理人:

摘要：

The present invention provides cytotoxic proteins comprising immunoglobulin-type binding regions for mediating cell-type specific targeting and Shiga toxin effector regions derived from A Subunits of members of the Shiga toxin family for effectuating cytotoxicity. The cytotoxic proteins have uses for selective killing of specific cell types and as therapeutics for the treatment of a variety of diseases, including cancers, immune disorders, and microbial infections.

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中国工程科技知识中心

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