PROBLEM TO BE SOLVED: To provide a microneedle sheet in which microneedles each having a desired shape are formed and to provide a method for manufacturing the microneedle sheet.SOLUTION: The microneedle sheet 42 includes: a sheet-like substrate 27 including a center portion Ac", a side peripheral portion Ad" surrounding the center portion Ac" and an outer edge portion Ao" surrounding the side peripheral portion Ad" the predetermined number of needles 28 extending by a first predetermined length from the center portion Ac" and one or more protrusions P extending by a length shorter than the first predetermined length from the side peripheral portion Ad".COPYRIGHT: (C)2012,JPO&INPIT【課題】所望の形状のマイクロニードルが構成されたマイクロニードルシート及びその製造方法を提供する。【解決手段】マイクロニードルシート42は、中央部Ac”と、当該中央部Ac”を取り囲む側周部Ad”と、側周部Ad”を取り囲む外縁部Ao”とを含むシート状の基材27と、中央部Ac”より第1の所定長だけ延在する所定数のニードル28と、側周部Ad”より第1の所定長より短い長さだけ延在する1つ以上の突起Pとを備える。【選択図】図10