Refers to Derivatives of pyrazole compounds - 4 - il - heterociclil - carboxamide of formula (i) wherein: R1 is H, alkyl aryl C1 - C6 12, 20, carbociclilo C3 - 12 among others R2 is H, alkyl aryl C1 - C6 12, 20, carbociclilo C3 - C12, among others X is Selected from (i), (ii) and (iii) R3 is H, CL, BR, aryl C6 - C20, among others R6 H or NH2.Preferred compounds are: 5-amino-2 - (2,6 - difluorofenil) - N - (1h-pyrazol-4-yl) - 4 - thiazole carboxamide (S) - 5 - amino - N - (5 - (3 - aminopiperidin - 1 - il) - 1h-pyrazol-4-yl) - 2 - (2 - 4 - difluorfenil) thiazole carboxamide 3-amino-n - (5 - (4 - aminoazepan - 1 - il) - 1 - methyl - 1h-pyrazol-4-yl) - 6 - (2 - fluorfenil picolinamida among others) In addition to that. A Pharmaceutical composition.This Compound is an inhibitor of the kinase PIM being useful in the treatment of cancer, immune disorders, cardiovascular diseases, Viral Infections, and Metabolic Disorders.SE REFIERE A COMPUESTOS DERIVADOS DEL PIRAZOL-4-IL-HETEROCICLIL-CARBOXAMIDA DE FORMULA (I) DONDE: R1 ES H, ALQUILO C1-12, ARILO C6-20, CARBOCICLILO C3-12 ENTRE OTROS R2 ES H, ALQUILO C1-12, ARILO C6-20, CARBOCICLILO C3-C12, ENTRE OTROS X SE ELIGE ENTRE (i), (ii) Y (iii) R3 ES H, Cl, Br, ARILO C6-C20, ENTRE OTROS R6 ES H O NH2. SON COMPUESTOS PREFERIDOS: 5-AMINO-2-(2,6-DIFLUOROFENIL)-N-(1H-PIRAZOL-4-IL)-TIAZOL-4-CARBOXAMIDA (S)-5-AMINO-N-(5-(3-AMINOPIPERIDIN-1-IL)-1H-PIRAZOL-4-IL)-2-(2,6-DIFLUORFENIL)TIAZOL-4-CARBOXAMIDA 3-AMINO-N-(5-(4-AMINOAZEPAN-1-IL)-1-METIL-1H-PIRAZOL-4-IL)-6-(2-FLUORFENIL)PICOLINAMIDA ENTRE OTROS. REFERIDA ADEMAS A UNA COMPOSICION FARMACEUTICA. DICHO COMPUESTO ES UN INHIBIDOR DE LA QUINASA PIM SIENDO UTIL EN EL TRATAMIENTO DEL CANCER, TRANSTORNOS INMUNES, ENFERMEDADES CARDIOVASCULARES, INFECCIONES VIRALES Y TRANSTORNO DEL METABOLISMO.
