2-oxo-1,2-dihydropyridine-3-carboxamide compounds and their use as inhibitors of PDK1

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专利权人:

INTERNATIONAL SOCIETY FOR DRUG DEVELOPMENT S.R.L.

发明人:

Simona Sestito,Simona Daniele,Claudia Martini,Simona Rapposelli,Guido Puricelli

申请号：

US15735468

公开号：

US10351548B2

申请日:

2016.06.10

申请国别(地区):

US

年份:

2019

代理人:

摘要：

The present invention concern a 2-oxo-1,2-dihydropyridine-3-carboxamide compound of Formula (I) and new 2-oxo-1,2-dihydropyridine-3-carboxamide compounds of Formula (II) in the treatment of pathologies which require an inhibitor of PDK1 enzyme such as diabetes, neurodegenerative diseases such as Alzheimer's and Prion Diseases, and tumors such as breast, and pancreatic cancers and glioblastoma, particularly glioblastoma.

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