The present invention relates to the use of one or more cannabinoids in combination with one or more anti-psychotic medicaments for use in the prevention or treatment of psychosis and psychotic disorders. Preferably the one or more cannabinoids are taken from the group: cannabidiol (CBD)； cannabidiolic acid (CBDA)； tetrahydrocannbidivarin (THCV)； tetrahydrocannbidivarinin acid (THCVA)； cannabichromene (CBC)； cannabichromenic acid (CBCA)； cannabigerol (CBG) and cannabigerolic acid (CBGA). Preferably the anti-psychotic medication is an atypical anti-psychotic medication.本發明係關於一或多種大麻素與一或多種抗精神病藥物之組合於預防或治療精神病或精神障礙的用途。該一或多種大麻素較佳為選自下列的群組：大麻二醇(CBD)；大麻二醇酸(CBDA)；四氫次大麻二酚(THCV)；四氫次大麻二酚酸(THCVA)；大麻色原烯(CBC)；大麻色烯酸(CBCA)；大麻萜酚(CBG)和大麻萜酚酸(CBGA)。該抗精神病藥物較佳為一種非典型抗精神病藥物。
