HADIDA-RUAH, Sara Sabina,KALLEL, Edward Adam,MILLER, Mark Thomas,PONTILLO, Joseph,ANDERSON, Corey,NUMA, Mehdi,FRIEMAN, Bryan A.,BEAR, Brian Richard,ARUMUGAM, Vijayalaksmi,HILGRAF, Nicole,MCCARTNEY, Ja
申请号：
ES11720264
公开号：
ES2599822T3
申请日:
2011.05.06
申请国别(地区):
ES
年份:
2017
代理人:
摘要：
A compound of formula I: ** ** Formula or a pharmaceutically acceptable salt thereof, wherein, independently for each occurrence, and optionally substituted with halo, cyano, oxoalcoxi, hydroxy, amino, nitro, aryl, haloalkyl, and alkyl as valency allows: a is ** ** formula or is selected from a heteroaryl or heterocyclic group of the formula: ** ** formula R1 is C1-C6 alkyl, C3-C8, C1-C6 alkoxy, halo, CN, OH , OR7, N (R7) 2, NR7SO2R7, SO2R7, SR7, SOR7, CO2R7, NR7COR7, NR7CO2R7, CON (R7) 2, SO2N (R7) 2, CF3, OCF3, OCHF2, heterocycloalkyl, aryl, heteroaryl O (CH2) 1-6-R8 in which up to two CH 2 units may be replaced by O, CO, S, sO, SO2, NR7； R2 is H, C1-C6 alkyl, C1-C6 haloalkyl, C3-C8, halo, aryl, COOH, CH2CF3, CHF2, CF3, CN, OH, OR7, CON (R7) 2, SO2R7, SR7, SOR7, SO2N (R7) 2, O (CH2) 1-6-R8 in which up to two CH 2 units may be replaced by O, CO, S, sO, SO2, CF2, or NR7； R3 is halo, C1-C6 alkyl or C3-C8 cycloalkyl, wherein up to two CH2 units may be replaced by O, CO, S, SO, SO2 or NR8； R4 is H, C1-C6 alkyl, C3-C8 cycloalkyl, C1-C6 alkoxy, halo, CN, OH, OR7, N (R7) 2, NR7SO2R7, SO2R7, SR7, SOR7, CO2R7, NR7COR7, NR7CO2R7, CON (R7 ) 2, SO2N (R7) 2, CHF2, CF3, OCF3, OCHF2, heterocycloalkyl, aryl, heteroaryl, or a linear, branched or cyclic (CH2) 1-8-R8 in which up to three CH2 units may be replaced with O, CO, S, SO, SO2, or NR7； R5 is H, C1-C6, C3-C8cycloalkyl, C1-C6alkoxy, C3-C8 cycloalkoxy, halo, CN, OH, OR7, N (R7) 2, NR7SO2R7, SO2R7, SR7, SOR7, CO2R7, NR7COR7 , NR7CO2R7, CON (R7) 2, SO2N (R7) 2, CF3, OCF3, OCHF2, heterocycloalkyl, aryl, heteroaryl, or a linear, branched or cyclic (CH2) 1-8-R8 in which up to three units CH2 may be replaced with O, CO, S, SO, SO2, or NR7； R6 is H, C1-C6 alkyl, C3-C8 cycloalkyl, C1-C6 alkoxy, halo, CN, OH, OR7, N (R7) 2, NR7SO2R7, SR7, SOR7, SO2R7, CO2R7, NR7COR7, NR7CO2R7, CON (R7 ) 2, SO2N (R7) 2, CF3, OCF3, OCHF2, heterocycloalkyl, aryl, heteroaryl, or a linear, branched or cyclic (CH2) 1-8-R8 in which up to three CH2 units may be
