Gordon, Stephen L.,Ganey, Timothy,Kronberg, James W.
申请号：
AU2006255660
公开号：
AU2006255660B2
申请日:
2006.05.30
申请国别(地区):
AU
年份:
2012
代理人:
摘要：
Compositions and methods are provided for modulating the growth, developmentand repair of bone, cartilage or other connective tissue. Devices and stimuluswaveforms are provided to differentially modulate the behavior of osteoblasts,chondrocytes and other connective tissue cells to promote proliferation, differentiation,matrix formation or mineralization for in vitro or in vivo applications. Continuous-modeand pulse-burst-mode stimulation of cells with charge-balanced signals maybe used. Bone, cartilage and other connective tissue growth is stimulated inpart by nitric oxide release through electrical stimulation and may be modulatedthrough co-administration of NO donors and NO synthase inhibitors. Bone, cartilageand other connective tissue growth is stimulated in part by release of BMP-2 andBMP-7 in response to electrical stimulation to promote differentiation of cells.The methods and devices described are useful in promoting repair of bone fractures,cartilage and connective tissue repair as well as for engineering tissue fortransplantation.
