ALEXANDER SCHWARZ,EVANGELOS LOUCAS TZANIS,HARRY QUANDT,MARK TODDMAN KIRBY,PETR KUZMA,RICHARD CAIZZA,SAGARIKA BOSE,STEPHEN BAI
申请号：
BR112014009819
公开号：
BR112014009819A2
申请日:
2012.10.24
申请国别(地区):
BR
年份:
2017
代理人:
摘要：
abstract a method of treatment, such as treating an estrogen-related disorder or a psychotic disorder, by implanting a reservoir-based drug delivery composition into a subject to systemically deliver a therapeutically effective amount of an active pharmaceutical ingredient (such as an aromatase inhibitor or risperidone) to the subject for a long period of time (eg, one month or one year). the drug delivery composition may include a rate-controlling excipient (eg, an elastomeric polymer) defining a reservoir containing at least one discrete solid dosage form (eg, one or more pellets), which includes an active pharmaceutical ingredient and optionally a sorption enhancer . abstract of the patent summary: "implantable drug release composition and method of treatment". The present invention relates to a method of treatment, such as treating an estrogen-related disorder or a psychotic disorder, by implanting a reservoir-type drug release composition into a subject to systemically deliver a therapeutically effective amount of a pharmaceutically active ingredient (such as an aromatase or risperidone inhibitor) for the subject over a long period of time (e.g., a month or a year). The drug release composition may include a rate control excipient (e.g., an elastomeric polymer) that defines a reservoir containing at least one distinct solid dosage form (e.g., one or more agglomerates), which includes a pharmaceutically active ingredient. active and optionally a sorption enhancer.abstract a method of treatment, such as treating an estrogen-related disorder or a psychotic disorder, by implanting a reservoir-based drug delivery composition into a subject to systemically deliver a therapeutically effective amount of an active pharmaceutical ingredient (such as an aromatase inhibitor or risperidone) to the subject for a long period of time (e.g., one month or one year). the drug delivery composition may include a rate-controlling excipient (e.g., an elastomeric polymer) defining a r
