Hyo Jeong Hong,Sang Jick Kim,Sun Ok Yoon,Myeong Hee Jang,Keun Soo Kim,Tae Sup Lee,Chang Woon Choi
申请号：
US11628423
公开号：
US08119132B2
申请日:
2005.05.06
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The present invention relates to humanized antibodies specific to a tumor-associated glycoprotein, TAG-72, and anticancer compositions comprising the humanized antibodies. In detail, the present invention relates to a humanized antibody which has enhanced antigen binding affinity by mutating a heavy chain of a humanized antibody PXA/HzK specific for TAG-72, an antibody which is prepared by replacing a light chain of the humanized antibody with a human light chain, and anticancer compositions including the antibodies.
