The present invention relates to a kind of compounds (I) for having and inhibiting Mst1/2 protein kinase activities, preparation method, the pharmaceutical composition comprising the compound, and these compounds and the pharmaceutical composition comprising the compound are preparing regeneration and reparation for promoting tissue and organ, stem cells hyperplasia and adult cell is promoted to dedifferente, immunosupress, prevention or treatment and the purposes in the disease medicament of neurological disorders related disease and ischaemic in organism