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INTERNAL VALVE DEVICE FOR DELIVERY OF MEDICINES
专利权人:
ИНК. (US);ЭВЕСТРА
发明人:
ШЕЙКИД Зе'ев (US),НИККИШ Клаус (DE),ДИНУНЦИО Джим (US),ЧЖАН Фын (US),ОМЕЛЧУК Марсело (US),ШЕЙКИД Зеев (US)
申请号:
RU2012146080/15
公开号:
RU2012146080A
申请日:
2011.03.28
申请国别(地区):
RU
年份:
2014
代理人:
摘要:
1. Intravaginal device for drug delivery, including: thermoplastic matrix without coating; iprogestin dispersed in a thermoplastic matrix. 2. The device according to claim 1, wherein the progestin compound is an etonogestrel. 3. The device according to claim 1, wherein the progestin compound is levonorgestrel. 4. The device according to claim 1, wherein the thermoplastic matrix further comprises an estrogen compound dispersed in a thermoplastic matrix. The device according to claim 4, wherein the estrogen compound is ethinyl estradiol. 6. The device according to claim 4, wherein the estrogen compound contains a nitrated derivative of estrogen having the structure: where R 1 is hydrogen, C 1 -C 6alkyl, cycloalkyl, or C 1-Sacyl; R 1 represents hydrogen or C 1 -C 6 alkyl; R 1 represents hydrogen, hydroxy or C 1 -C 6alkyl ; R 1 is hydrogen or C 1-6 alkyl; wherein any of R 1 and R 2 is, independently of one another, hydrogen or nitrate; and where at least one of R and R represents a nitrate group. The device according to claim 1, wherein the thermoplastic matrix contains an ethylene vinyl acetate copolymer. The device according to claim 1, wherein the thermoplastic matrix contains one or more hydrophilic matrix substances. The device according to claim 1, wherein the thermoplastic matrix contains one or more hydrophobic matrix substances. The device according to claim 1, wherein the thermoplastic matrix contains an ethyl vinyl acetate copolymer and one or more hydrophilic matrix substances. The apparatus of claim 1, wherein the apparatus is substantially annular in shape. The device according to claim 1, where thermoplastic1. Внутривлагалищное устройство для доставки лекарственного средства, включающее:термопластический матрикс без покрытия; ипрогестин, диспергированный в термопластическом матриксе.2. Устройство по п. 1, где прогестиновое соединение представляет собой этоногестрел.3. Устройство по п. 1, где прогестиновое соединение представляет собой левоноргестрел.4. Ус
来源网站:
中国工程科技知识中心
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