Theresa L. O'Keefe;Walter Newman;Shixin Qin;Robert A. Obar
发明人:
Walter Newman,Shixin Qin,Theresa L. O'Keefe,Robert A. Obar,Theresa L. OKeefe
申请号：
US12897453
公开号：
US08846047B2
申请日:
2010.10.04
申请国别(地区):
US
年份:
2014
代理人:
摘要：
In various embodiments, the present invention is drawn to antibodies or antigen-binding fragments thereof that bind to a vertebrate high mobility group box (HMGB) polypeptide, methods of detecting and/or identifying an agent that binds to an HMGB polypeptide, methods of treating a condition in a subject characterized by activation of an inflammatory cytokine cascade and methods of detecting an HMGB polypeptide in a sample.
