To provide a novel composition which is effective for treatment or preventing of limb syndrome in which, there is no effective coping method therefor, since a crisis mechanism of limb syndrome is unknown, regardless of existence of need of treatment or prevention which is important in continuation of a factor medicine and QOL improvement of a patient or the like.SOLUTION: There is provided a composition for treating or preventing limb syndrome including as an active ingredient, a substance for capturing or removing active oxygen. The composition of the invention can be provided as a skin external preparation for patient who suffers from limb syndrome, for example, a medicine for treatment of limb syndrome.SELECTED DRAWING: Figure 8【課題】原因薬剤の継続や患者のＱＯＬ向上などの点で重大な治療または予防ニーズの存在にも関わらず、その発症機序は不明であり、有効な対処法が存在しない状況にある手足症候群の治療または予防に有効な新規組成物を提供することを目的とする。【解決手段】活性酸素を捕捉または除去する物質を有効成分とする、手足症候群を治療または予防するための組成物を提供する。本発明の組成物は、手足症候群の患者向けの皮膚外用剤、例えば手足症候群治療用医薬品として提供することができる。【選択図】図８
