Suzuki, Kazuo,Kelleher, Anthony Dominic,Symonds, Geoffrey Phillip,Ahlenstiel, Chantelle Lisa Evelyn
申请号：
AU2016265003
公开号：
AU2016265003A1
申请日:
2016.02.15
申请国别(地区):
AU
年份:
2017
代理人:
摘要：
The present disclosure provides for an expression vector comprising (i) at least one nucleic acid sequence encoding a transcriptional gene silencing element； and (ii) at least two other nucleic acid sequences selected from the group consisting of a nucleic acid sequence that encodes a nucleic acid molecule that inhibits an HIV co-receptor； a nucleic acid sequence that encodes an HIV fusion inhibitor protein； a nucleic acid sequence encoding an inhibitor of HIV replication； and a nucleic acid sequence encoding an inhibitor of viral entry. The combination of the three mechanisms in a single expression vector provides for novel means of inhibiting HIV-1.
