The skin organizational improvement material which is offered by this invention the tissue bud cell of organization origin inside the buccal cavity of the human or other mammal is formed as subject. It is desirable, the above-mentioned tissue bud cell the gum tissue bud cell of the person and/or is the dental root membrane tissue bud cell, blood vessel endotherium growth factor (VEGF) and/or angular conversion cell growth factor (KGF) it is superior in production talent.本発明によって提供される皮膚組織改善材は、ヒト又は他の哺乳動物の口腔内組織由来の線維芽細胞を主体として構成される。好ましくは、上記線維芽細胞はヒトの歯肉線維芽細胞及び/又は歯根膜線維芽細胞であり、血管内皮細胞増殖因子(VEGF)及び/又は角化細胞増殖因子(KGF)の産生能に優れる。
