A renal denervation feedback method is described that performs a baseline measurement of renal nerve plexus electrical activity at a renal vessel denervates at least some tissue proximate the renal vessel after performing the baseline measurement performs a post-denervation measurement of renal nerve plexus electrical activity at the renal vessel, after the denervating and assesses denervation of the renal vessel based on a comparison of the baseline measurement and the post-denervation measurement of renal nerve plexus electrical activity at the renal vessel.