SNYDER, EVAN Y.,LYNCH, WILLIAM P.,BREAKEFIELD, XANDRA O.,ABOODY, KAREN
申请号：
CA2313169
公开号：
CA2313169C
申请日:
1999.09.17
申请国别(地区):
CA
年份:
2013
代理人:
摘要：
One of the impediments to the treatment of some human brain tumors (e.g.,gliomas) has been the degree to which they expand, migrate widely, andinfiltrate normal tissue. We demonstrate that a clone of multipotent neuralprogenitor stem cells, when implanted into an experimental glioma, willmigrate along with and distribute themselves throughout the tumor injuxtaposition to widely expanding and aggressively advancing tumor cells,while continuing to express a foreign reporter gene. Furthermore, drawnsomewhat by the degenerative environment created just beyond the infiltratingtumor edge, the neural progenitor cells migrate slightly beyond and surroundthe invading tumor border. When implanted at a distant site from the tumor bed(e.g., into normal tissue, into the contralateral hemisphere, into the lateralventricles) the donor neural progenitor/stem cells will migrate through normaltissue and specifically target the tumor cells. These results suggest theadjunctive use of neural progenitor/stem cells as a novel, effective deliveryvehicle for helping to target therapeutic genes and vectors to invasive braintumors that have been refractory to treatment.
