ФАЙФ Гвендолин,ХОУЛМГРЕН Эрик,МАСС Роберт Д.,НОВОТНИ Уилльям
申请号：
RU2014109776
公开号：
RU2014109776A
申请日:
2014.03.13
申请国别(地区):
RU
年份:
2015
代理人:
摘要：
1. A method of treating cancer in a human patient, comprising administering to the patient an effective amount of an anti-VEGF antibody and monitoring the patient for gastrointestinal perforation. The method of claim 1, further comprising administering to the patient an antineoplastic agent, wherein said antineoplastic agent comprises at least one chemotherapeutic agent. The method according to any one of paragraphs. 1 or 2, where the cancer is selected from the group consisting of breast cancer, colorectal cancer, rectal cancer, non-small cell lung cancer, non-Hodgkin lymphoma (NHL), renal cell cancer, prostate cancer, liver cancer, pancreatic cancer, soft tissue sarcoma , Kaposi’s sarcoma, carcinoid carcinoma, head and neck cancer, melanoma, ovarian cancer, mesothelioma, multiple myeloma and glioblastoma. 4. The method according to any one of paragraphs. 1 or 2, where the cancer is metastatic. 5. The method according to any one of paragraphs. 1 or 2, where the patient has not previously been treated. 6. The method of claim 2, wherein the chemotherapeutic agent is selected from the group consisting of alkylating agents, antimetabolites, folic acid analogues, pyrimidine analogs, purine analogues and related inhibitors, vinca alkaloids, epipodophyll toxins, antibiotics, L-asparaginase, topoisomerase inhibitor, interferons, coordination complexes of platinum, substituted urea anthracenedione, methylhydrazine derivatives, adrenal cortical suppressant, adrenocorticosteroids, progestins, estrogens, antiestrogen, androgens, and ntiandrogen and gonadotropin-releasing hormone analogue. 7. The method of claim 6, wherein the chemotherapeutic agent is selected from the group consisting of 5-fluorouracil (5-FU), leucovor1. Способ лечения рака у пациента человека, включающий введение пациенту эффективного количества антитела против VEGF и отслеживание пациента на желудочно-кишечное прободение.2. Способ по п. 1, дополнительно включающий введение пациенту антинеопластического аген
