Disclosed herein is a framework for facilitating patient signal analysis. In accordance with one aspect, actiniform segmentation is performed on patient signal data waveform based on an actiniform shape. The actiniform shape is centered at a peak of the waveform and includes connection lines extending from the peak to key time points of the patient signal data waveform. Actiniform parameters may be extracted from the segmented patient signal data waveform. Additionally, one or more actiniform ratios may be determined based on the actiniform parameters to monitor changes in the patient signal data waveform.