Jorg Breitenbach,Bernd Liepold,Didier R. Lefebvre,Steffen Bossmann,Benedikt Steitz,Peter Hölig
申请号：
US13500013
公开号：
US20120252851A1
申请日:
2010.10.05
申请国别(地区):
US
年份:
2012
代理人:
摘要：
A delivery system for sustained release of a calcium-channel blocking agent is adapted for introduction in the cerebrospinal fluid of a subject. The delivery system comprises a solid dispersion product of a calcium-channel blocking agent in a mixture of a (i) first poly(lactide-co-glycolide) having a molecular weight distribution centered around a first number average molecular weight Mn1 and a (ii) second poly(lactide-co-glycolide) having a molecular weight distribution centered around a second number average molecular weight Mn2, wherein Mn1 is in the range of from 2000 to 3000 g/mol and the ratio of Mn1/Mn2 is from 1.8 to 3.5. The delivery system is deposited in the vicinity of or adjacent to a blood vessel showing vasospasm or suspected of developing vasospasm.
