BOCK, Mark Gary,MOEBITZ, Henrik,PANIGRAHI, Sunil Kumar,PODDUTOORI, Ramulu,SAMAJDAR, Susanta
申请号:
TN2015000574
公开号:
TN2015000574A1
申请日:
2014.08.14
申请国别(地区):
TN
年份:
2017
代理人:
摘要:
The present invention relates to compounds of formula I in which n, R<;sub>;1 <;/sub>;, R<;sub>;2<;/sub>;,R<;sub>;3a <;/sub>;, R<;sub>;4 <;/sub>; and R<;sub>;5 <;/sub>;are defined in the Summary of the Invention; capable of inhibiting the activity of MEK. The invention further provides a process for the preparation of compounds of the invention, pharmaceutical preparations comprising such compounds and methods of using such compounds and compositions in the management of hyperproliferative diseases like cancer.