FORMULATIONS CONTAINING PYRIDAZINE COMPOUNDS FOR THE TREATMENT OF NEUROINFLAMMATORY DISEASES. The invention relates to chemical compounds, compositions and methods of making and using them. In particular, the invention provides compounds selected from the pyridazine of formula (I) is independently hydrogen, hydroxy, alkyl, alkenyl, alkynyl, alkylene, alkenylene, alkoxy, alkenyloxy, cycloalkyl, cycloalkenyl, cycloalkoxy, aryl, aryloxy, arylalkoxy, aroyl , heteroaryl, heterocyclic, acyl, acyloxy, amino, imino, azido, thiolate, thioalkyl, thioalkyl, thioaryl, nitro, cyano, halo, sulfate, sulfenyl, sulfinyl, sulfonyl, sulfonate, sulfoxide, silyl, silyloxy, silylalkyl, silylthio = O, = S, phosphonate, ureido, carboxyl, carbonyl, carbamoyl, or carboxamide； and X is optionally pyrimidinyl or substituted pyridazinyl, an isomer, a pharmaceutically acceptable salt, or derivative thereof. The invention further relates to compositions comprising the compounds, and methods of using the compounds and compositions for modulating cell pathways, for treating or preventing inflammatory diseases, for screening, drug selection, and therapeutic applications.FORMULAçõES CONTENDO COMPOSTOS DE PIRIDAZINA PARA O TRATAMENTO DE DOENçAS NEUROINFLAMATóRIAS. A invenção relaciona-se aos compostos químicos, às composições e aos métodos de fazer e de usar o mesmos. Em particular, a invenção fornece compostos selecionados do piridazina da fórmula (i) é independente hidrogênio, hidróxila, alquila, alquenila, alquinila, alquileno, alquenileno, alcoxi, alqueniloxi, cicloalquil, cicloalquenil, cicloalquinil, cicloalcoxi, arilo, ariloxi, arilalcoxi, aroil, heteroaril, heterociclic, acílico, aciloxi, amino, imino, azido, tiolato, tioalquil, tioalcoxi, tioaril, nitro, ciano, halo, sulfato, sulfenil, sulfinil, sulfonil, sulfonato, sulfóxido, silil, sililoxi, sililalquil, sililtio, =0, =S, fosfonate, ureido, carboxil, carbonila, carbamoil, ou carboxamida； e X é opcionalmente pirimidinil ou piridazinil substi
