The present invention relates to a dosage form comprising a physiologically effective amount of a physiologically active substance (A), a synthetic, semi-synthetic or natural polymer (C), optionally one ormore physiologically acceptable auxiliary substances (B) and optionally a synthetic, semi-synthetic or natural wax (D), wherein the dosage form exhibits a resistance to crushing of at least 400 N and wherein under physiological condition the release of the physiologically active substances (A) from the dosage form is at least partially delayed.本發明係關於一種包含生理上有效量之生理活性物質(A)、合成、半合成或天然聚合物(C)、視需要的一或多種生理上可接受的輔助物質(B)和視需要的合成、半合成或天然蠟(D)之劑型,其中該劑型展現至少400 N之抗粉碎性,且其中在生理條件下該生理活性物質(A)從該劑型之釋出至少部分被延緩。