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LIPOSOMES CONTAINING OLIGOPEPTIDE FRAGMENTS OF MYELIN BASIC PROTEIN, A PHARMACEUTICAL COMPOSITION AND A METHOD FOR TREATMENT OF MULTIPLE SCLEROSIS
专利权人:
Lipoxen Technologies Limited
发明人:
Gabivov, Alexander,Belogurov, Alexey,Ponomarenko, Natalia,Smirnov, Ivan,Bacon, Andrew,Gregoriadis, Gregory
申请号:
AU2016225843
公开号:
AU2016225843A1
申请日:
2016.09.07
申请国别(地区):
AU
年份:
2016
代理人:
摘要:
#$%^&*AU2016225843A120160929.pdf#####ABSTRACT [0292] A composition for the treatment of multiple sclerosis comprises a first myelin basic protein (MBP) peptide linked to a first vector, the first MBP peptide consisting of the amino acid sequence: (Rl)a-Pi-R 2)b wherein P1 is an amino acid sequence having at least 85% identity to an amino acid sequence selected from the group consisting of SEQ ID NOS: 1-3 each of R1 and R2 are amino acid sequences independently consisting of from 1 to 10 amino acids and each of a and b are independently zero or one. Compositions of immunodominant peptides of myelin basic protein are encapsulated in manosylated liposomes. In a specific embodiment, the compositions comprise myelin basic protein (BMP) peptides MBP(46-62), MBP(124-139), and MBP(147-170).
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/
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