INTEGRATED BIOTHERAPEUTICS, INC.;INTEGRAL MOLECULAR, INC.
发明人:
Mohammad Javad AMAN,Katie A. HOWELL,Edgar DAVIDSON,Benjamin J. DORANZ
申请号：
US16084151
公开号：
US20190381162A1
申请日:
2017.03.27
申请国别(地区):
US
年份:
2019
代理人:
摘要：
Provided herein are methods of incorporating substitutions of specified residues into a filovirus GP in order to increase immunogenicity and/or broaden the cross-reactivity of the protective immune response against other filovirus members. Also provided herein are mutant filovirus GPs comprising such substitutions.
