SVENDSEN, ALLAN,SKJOET, MICHAEL,YAVER, DEBBIE,CHRISTENSEN, LARS LEHMANN HYLLING,LARSEN, SIGNE ESKILDSEN,LUNDIN, NINA,LAMSA, MICHAEL,GREGORY, PETER COLIN
申请号：
CA2961041
公开号：
CA2961041C
申请日:
2007.12.12
申请国别(地区):
CA
年份:
2020
代理人:
摘要：
The pharmaceutical use of lipases related to the Thermomyces lanuginosus(Humicolalanuginosa) lipase comprising amino acids 1-269 of SEQ ID NO: 2, optionally incombinationwith a protease and/or an amylase. Examples of medical indications are:Treatment of digestivedisorders, pancreatic exocrine insufficiency (PEI), pancreatitis, cysticfibrosis, diabetes type I,and/or diabetes type IL The lipases of the invention have, e.g., an improveddigestionperformance in vitro, an improved activity at a pH in the neutral range, animproved stability atlow pH, and are stable against protease-degradation, and/or are stable in thepresence of Mpepsin and bile salts. The invention also relates to methods of determiningdigestionperformance in vitro of lipases, as well as to certain novel variants of thelipase of T.lanuginosus.
