BARSANTI, PAUL A,HU, CHENG,JIN, JEFF,KEYES, ROBERT,KUCEJKO, ROBERT,LIN, XIAODONG,PAN, YUE,PFISTER, KEITH B,SENDZIK, MARTIN,SUTTON, JAMES,WAN, LIFENG
申请号：
NZ59755110
公开号：
NZ597551A
申请日:
2010.07.28
申请国别(地区):
NZ
年份:
2013
代理人:
摘要：
597551 Disclosed herein is a compound of formula (I), wherein the variables are defined in the specification； a pharmaceutical composition comprising said compound； and the use of said compound in the treatment of a disease or condition mediated by CDK9, such as cancer, cardiac hypotrophy, HIV, and inflammatory diseases. Embodiments of the compound include the following: 3,5'-dichloro-N2'-(trans-4-(((R)-2,2-dimethy-1-1,3-dioxolan-4-yl)methyl)aminocyclohexyl)-N6-((tetrahydro-2H-pyran-4-yl)methyl)-2,4'-bipyridine-2',6-diamine, and trans-4-(5-chloro-4-(6-((tetrahydro-2H-pyran-3-yl)methyl)aminopyrazin-2-yl)pyridin-2-yl-amino)cyclohexanol.
